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Tirza 2.5 AutoGuarded Prefilled Syringe
Therapeutic Class: Dual GIP and GLP-1 Receptor Agonist
Dosage Form: Prefilled Syringe for Subcutaneous Injection
Strengths Available: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg
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✅ Description:
Tirza is indicated as an adjunct to diet and exercise to enhance glycemic control in adults with type 2 diabetes mellitus.
Limitations of Use
Not studied in individuals with a history of pancreatitis.
Not approved for type 1 diabetes mellitus.
⚠️ Always take under the supervision of a registered physician.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Pharmacology
Tirzepatide is a synthetic 39-amino-acid peptide with a C20 fatty diacid moiety, enhancing its albumin binding and extending its half-life.
It selectively activates GIP and GLP-1 receptors, boosting insulin secretion (first and second phase) and reducing glucagon—both in a glucose-dependent manner.
✔️ Side Effects
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Decreased appetite
- Dyspepsia
- Abdominal pain
✔️ Administration Instructions
- Inject once weekly any time of the day, with or without meals.
- Injection sites: Abdomen, thigh, or upper arm—rotate sites with each dose.
- Do not mix with insulin. If used together, inject at separate sites (not adjacent).
- Inspect syringe for discoloration or particles before use.
- Do not freeze. Discard if frozen or dropped on a hard surface.
- Latex allergy warning: Needle cover contains dry natural rubber (latex derivative).
✔️ Dosage & Administration
Route: Subcutaneous injection
Start with 2.5 mg once weekly (initiation dose, not for glycemic control)
After 4 weeks, increase to 5 mg once weekly
Further titration: Increase in 2.5 mg increments every 4 weeks as needed
Maximum dose: 15 mg once weekly
Pediatrics (<18 years): Safety and efficacy not established.
Geriatric patients: No dosage adjustment based solely on age.
Renal or hepatic impairment: Monitor closely; consider dose adjustments based on tolerability.
Missed Dose:
- Administer within 96 hours (4 days).
- If >4 days have passed, skip the missed dose and resume the regular schedule.
- The weekly injection day may be changed, but maintain at least 72 hours between doses.
✔️ Interaction
- Insulin or insulin secretagogues (e.g., sulfonylureas): Risk of hypoglycemia—dose adjustment may be needed.
- Oral medications: Tirza delays gastric emptying, potentially affecting absorption of critical drugs (e.g., warfarin).
- Hormonal contraceptives (oral): Recommend switching to a non-oral or barrier method for 4 weeks after initiation and after any dose escalation.
- Non-oral contraceptives are not affected.
✔️ Contraindications
- Hypersensitivity to tirzepatide or any component of the formulation
- Personal or family history of medullary thyroid carcinoma (MTC)
- History of multiple endocrine neoplasia syndrome type 2 (MEN 2)
✔️ Use in Pregnancy & Lactation
- Use during pregnancy only if benefits outweigh risks—uncontrolled diabetes also poses fetal risks.
- During breastfeeding, weigh potential effects on the infant against maternal benefit.
- Consider alternative treatments if needed.
✔️ Precautions & Warnings
- Thyroid tumors (MTC): Counsel patients and monitor for symptoms (e.g., neck mass, dysphagia).
- Pancreatitis: Discontinue immediately if suspected.
- Hypoglycemia: May need to reduce insulin or sulfonylurea dose.
- Hypersensitivity: Discontinue and manage accordingly.
- Renal impairment: Monitor function if severe GI symptoms develop.
- Diabetic retinopathy: Monitor for progression.
- Gallbladder disease: Evaluate if cholelithiasis is suspected.
✔️ Storage Conditions
- Store in a refrigerator (2°C to 8°C)
- Do not freeze
- Protect from light
- Keep out of reach of children
- For use only with a registered physician's prescription
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
